Can You Take Phentermine and Ozempic Together? It Depends

Taking Phentermine with Ozempic

Phentermine and Ozempic have both become popular medications to take for weight loss. Although they work using slightly different mechanisms, Phentermine and Ozempic both encourage a reduction in appetite, causing you to eat less and encouraging your body to rely on burning body fat for energy.

With the goal of boosting their weight loss efforts as much as possible, some people consider taking Phentermine and Ozempic together. Though both these medications have benefits for weight loss on their own, there are still questions about whether it is safe or effective to take them together.

If you are considering taking both together, there are a few considerations you should keep in mind—this starts with seeking the advice of your doctor. This guide outlines what you should know about taking Ozempic and Phentermine together.

What Is Phentermine?

Phentermine is a prescription medication that reduces appetite and is considered one of the most commonly used anti-obesity medications in the United States. Because it can help make you feel less hungry or feel full longer, it offers benefits for weight loss, encouraging you to eat fewer calories. As a result, your body is less likely to store excess calories as body fat.

Phentermine works by interacting with the nervous system as a stimulant—the medication encourages the production of norepinephrine and dopamine. By doing so, the medication increases feelings of fullness and quells cravings that may cause you to eat more.

A phentermine dose is usually taken as a pill or tablet once daily. Compared to other weight loss medications, Phentermine is considered a short-term regimen, as it was initially approved for use up to 12 weeks by the Food and Drug Administration (FDA), but some healthcare providers may recommend a longer regimen depending on the case.

What Is Ozempic?

Ozempic is a medication originally formulated for type 2 diabetes that was also found to offer benefits for weight loss. Because of its weight loss benefits, Ozempic is now frequently prescribed off-label by medical providers for weight loss.

Like Phentermine, Ozempic helps to suppress appetite and encourage feelings of fullness. However, Ozempic works using a different mechanism. The key active ingredient in Ozempic is semaglutide, also found in medications like Wegovy and Mounjaro.

Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist, which means that it mimics the GLP-1 hormone in the body—the same hormone that signals to the brain to slow stomach emptying and reduce appetite.

Ozempic is usually taken by a once-weekly injection, and an Ozempic regimen can last indefinitely, depending upon a healthcare provider’s recommendations.

Can You Take Phentermine with Ozempic?

Currently, whether you can take Phentermine with Ozempic safely is still unclear—there is still a significant amount of research to be done about the topic, with not much available in the medical community yet today. Some doctors may allow you to take Phentermine with Ozempic, while others may recommend against it due to the lack of information surrounding how they may interact with each other. All together, it depends on you and the advice of your doctor.

Phentermine is commonly combined with some other weight loss medications, like Qsymia, which features the key ingredient topiramate. However, this does not mean that it will automatically combine well with other weight-loss medications.

Some medical providers will consider a patient’s medical history and recommend combining Phentermine with Ozempic to reach their weight loss goals. However, this should only be decided on a case-by-case basis.

You should not take Phentermine and Ozempic together if:

• You are pregnant or breastfeeding
• You have a thyroid disorder
• You have a history of pancreatitis
• You have a history of mental health conditions like anxiety or depression
• You have a history of heart conditions
• You have a kidney or liver disorder 

Safety Concerns of Combining Phentermine and Ozempic

The main concern surrounding whether you can take Phentermine with Ozempic revolves around how they might interact with each other in the body. It’s important to consider several things before you adjust your medication regimen.

Common side effects of Phentermine may include a faster heart rate, sleeplessness, nervousness, dry mouth, and constipation. Meanwhile, side effects of Ozempic can include nausea, intestinal pain, diarrhea, and vomiting. Facing side effects from both could be uncomfortable and have negative health implications.

Typically, the body needs time to adjust to any new medication, as it can alter your body’s hormone balance, interact with neurotransmitters, and more. Combining two medications may magnify this effect and require more time for your body to adjust, resulting in longer-lasting or more significant side effects.

Of course, everyone is different and may react differently, so this may or may not be the case, but it is important to be aware of. If you do notice significant side effects from either medication, you should inform your medical provider as soon as possible.

Other Factors To Consider Before Combining the Two

If you are thinking about taking Ozempic and Phentermine together, it’s important to make sure you plan proactively and take a well-thought-out approach. First and foremost, before you consider combining Phentermine and Ozempic, you should always consult your doctor about the potential risks and benefits.

Before combining the two medications, you and your doctor should consider the following:

• Individual health conditions – Some people may be more prone to side effects than others or have a history of medical conditions that can pose risks for combining both medications.
• Dosage and administration – If you take both medications together, you will likely need to adjust your dose and medication regimen compared to taking just one by itself. Your doctor will likely start you with low doses and gradually increase them depending on how your body responds.
• Monitoring and follow-up – If your doctor supports combining the two medications, they should perform regular monitoring and consistent check-ups to assess their success and how your body is responding.

Consistent check-ins will be key to determining the efficacy of combining these two medications. These will provide the opportunity to monitor your health, catch any negative effects resulting from your medical history, and reassess your dosage. You and your doctor may find that your body responds well to a combined regimen of Phentermine and Ozempic, while you may find that taking both together leads to complications.

Alternative Approaches To Weight Loss

With the uncertainty and potential risks that surround weight loss medications like Phentermine and Ozempic, many people find it more worthwhile to pursue alternative weight loss approaches. Medications also come with other question marks, as weight loss from medication is often unsustainable, resulting in the phenomenon known as the Ozempic rebound, where patients regain weight shortly after stopping their medication regimen.

Some alternative approaches to medications that can promote weight loss with fewer risks and less uncertainty include:

• Diet and lifestyle changes – Adjusting your diet to include more nutrient-rich whole foods will help you control your appetite and nourish your body with the energy you need while minimizing cravings for unhealthy fatty foods.
• Exercise and behavioral modifications – Incorporating more physical activity through strength training can help you burn more calories, which can result in improved metabolic function and a potential loss of body fat.
• Improved lifestyle adjustments – Lifestyle modifications like improved sleep hygiene, increased stress management strategies, and a higher water intake.

These weight loss strategies are often the most reliable. With a natural approach to weight loss, centered around eating nutritious whole foods and building healthy habits, you don’t have to worry about potential side effects. Plus, once you build these habits, you are more likely to sustain them long-term, resulting in lasting weight loss.

If you need help jumpstarting your journey to lasting weight loss, turn to our team of board-certified nutritionists and expert weight loss coaches here at re:vitalize. We offer technology-informed, nutrition-centered, and personalized weight loss programs to maximize long-term success. 

Explore Holistic Weight Loss Plans with re:vitalize

Ultimately, if you have the approval of your doctor, you can take Phentermine and Ozempic together. If you do, though, you should maintain consistent check-ups with your doctor to ensure that your body responds well to both. However, regardless of whether you take one or multiple, weight loss medications come with several question marks. To avoid these question marks and achieve undeniable weight loss success, you should consider a natural, medication-free approach.

When you take a natural approach to weight loss, you don’t have to worry about the risks of combining medications or their efficacy. There are no side effects to healthy eating. At re:vitalize weight loss & wellness, we offer personalized weight loss programs centered around healthy eating to promote weight loss success without the need for medication.

With the help of our board-certified nutritionists and expert weight loss coaches, we’ll empower you to lose weight and keep it off long-term without medications. Our Flexible Weight Loss programs and Weight Loss and Metabolic Reset programs provide you with the support and accountability needed to sustain success.

Schedule a 1:1 virtual or in-person consultation with our team to start the last weight loss journey you’ll ever need.